Usa research associate ii scientific - united states, cambridge bay
onsite position
precision oncology spatial transcriptomics research associate ii
job overview/department description:
precision oncology is a dedicated oncology research group focused on increasing success rates in early development by applying high content data and analytics to inform both research and early development decisions. we work as the integrated analytical arm of drug discovery teams and embrace a bedside to bench and back approach to understand at the molecular level cancer subtypes, immune context, and drug response in patients. molecular data (cytometric, single cell and spatial data) as well as advanced statistical and machine learning methods are used to identify targets, and animal models for hypothesis testing, poc indications, and biomarkers for advancing our cancer drug discovery programs.
we are seeking a self-motivated candidate with a strong background in immunochemistry, histology, and imaging to help support our effort in spatial biology. additional technical experience in geomx digital profiler (dsp) and/or molecular biology are desirable. the successful candidate we are looking for is an independent problem-solver, detail oriented and agile. key responsibilities include experimental design, implementation, and troubleshooting of high-multiplex spatial assays (both independently and in collaboration with colleagues). colleague must feel comfortable presenting summarized experimental results.
key responsibilities:
1. responsible for the execution and analysis of experiments and analytical procedures.
• handle human and non-human ffpe or ff tissue sections
• perform histologic and immunofluorescent staining of slide-based samples
• validate/optimize/troubleshoot new antibodies/panels for fihc based assays
• perform slide preparation and data collection for transcriptional profiling of ffpe tissue sections
• prepare sample libraries for next generation sequencing (ngs)
2. display an investigative or technological orientation in designing, executing and interpreting experiments and analytical procedures with minimal guidance.
3. investigate basic technical problems and performs routine scientific procedures and experiments under general supervision.
4. plan and prioritize concurrent experimental procedures.
5. integrate, compile, and tabulate data and assist supervisor in the analysis and interpretation of the results.
6. may provide oral presentations on results to other department members.
basic qualifications:
• masters degree (preferred) or bachelors degree in biology or related discipline
• minimum of 3 years of relevant industry experience (demonstrated abilities with handling ffpe tissue samples. experience with techniques such as ihc/if, imaging, histology required)
• self-motivated and organized with attention to detail and ability to multi-task
• excellent communication and time-management skills
• strong written and spoken english skills
• familiarity with common computer programs (ms word, excel and powerpoint)
• familiarity with drafting protocols and presenting scientific results
• attention to detail and organization
• motivated self-starter
• good problem-solving abilities
• strong interpersonal communication and capacity to work as part of a team
• flexibility, adjusting to a fast-paced, goal-oriented environment and willingness to expand and broaden skillset.
preferred qualifications:
• experience with antibody validation, optimization and troubleshooting for fihc is preferred
• experience in automated slide stainers like leica bond rx is preferred
• experience on implementing one of the currently available spatial transcriptomics technologies such as geomx (nanostring), visium (10x genomics), or other similar platforms is preferred
• experience with next generation sequencing techniques is preferred
• experience in image analysis software like halo, visiopharm, imagej is preferred
equal opportunity employer/veterans/disabled
the company will consider qualified applicants with arrest and conviction records
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